Genetic Analysis of Autoimmune Disease

Genetic Analysis of Autoimmune Disease

so that parental chromosomes often bear different *Division of Basic Sciences National Jewish Center for Respiratory Medicine alleles allowing fully informative tracking of chromosomes from parents to affected progeny. Microsatellites and Immunology 1400 Jackson Street are flanked by unique sequences to which polymerase chain reaction primers can be designed, and many as-Denver, Colorado 80206 ...

Genetic Determinants of Autoimmune Disease

New Genetic Insights from Autoimmune Thyroid Disease

The autoimmune thyroid diseases (AITDs) (Graves' disease and Hashimoto's thyroiditis) are complex genetic diseases which most likely have more than 20 genes contributing to the clinical phenotypes. To date, the genes known to be contributing fall into two categories: immune regulatory genes (including HLA, CTLA4, PTPN22, CD40, CD25, and FCRL3) and thyroid-specific genes (TG and TSHR). However, ...

Genetic Analysis of Adult-Onset Autoimmune Diabetes

OBJECTIVE In contrast with childhood-onset type 1 diabetes, the genetics of autoimmune diabetes in adults are not well understood. We have therefore investigated the genetics of diabetes diagnosed in adults positive for autoantibodies. RESEARCH DESIGN AND METHODS GAD autoantibodies (GADAs), insulinoma-associated antigen-2 antibodies (IA-2As), and islet cell autoantibodies were measured at tim...

Genetic susceptibility to autoimmune liver disease.

Autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are considered as putative autoimmune diseases of the liver. Whereas strong evidence that bacterial infection may trigger PBC exists, the etiologies for PSC and AIH remain unknown. Although there have been significant discoveries of genetic polymorphisms that may underlie the susceptibility to t...